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Researchers develop tool to predict how patients will respond to common multiple sclerosis drug

Brazilian researchers, in partnership with French institutions, have developed a tool that can predict how patients will respond to natalizumab, one of the most commonly used drugs for treating multiple sclerosis.

25 Sep 2025

Patient-derived organoids advance cancer therapy and vaccines

Tiny, three-dimensional organoid models are reshaping cancer research by recreating the intricate architecture and diversity of human tumors.

25 Sep 2025

Calcium-induced release identified as key driver of dangerous muscle disorders

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release.

25 Sep 2025

Antidepressant fluoxetine alters brain energy use and boosts neural plasticity

A new study shows that the widely used antidepressant fluoxetine does more than boost serotonin levels: it changes how brain cells manage their energy and rebuild their connections, potentially helping the brain "loosen up" and adapt during depression treatment.

25 Sep 2025

Robotic bronchoscope reaches tiny, hard-to-access lung tumors with high accuracy

A cutting-edge bronchoscope that is guided with the help of a robot can reach very small tumors growing in hard-to-reach parts of the lung, according to results of a gold-standard randomized-controlled trial that will be presented at the European Respiratory Society (ERS) Congress in Amsterdam, the Netherlands.

25 Sep 2025

Babies living with dogs show better lung function and reduced asthma rates

Babies exposed to dog allergens in the home have a lower risk of developing asthma by the age of five years, according to research that will be presented at the European Respiratory Society (ERS) Congress in Amsterdam, the Netherlands.

25 Sep 2025

UdeM studies make a major breakthrough in predicting neurodegenerative diseases

An international research team led by Université de Montréal medical professor Shady Rahayel has made a major breakthrough in predicting neurodegenerative diseases.

25 Sep 2025

Alcohol raises dementia risk at every level of drinking, genetic study shows

Researchers using two major cohorts and Mendelian randomization found that alcohol consumption, whether light or heavy, raises the risk of dementia. Genetic evidence shows no safe level of drinking, challenging the belief that moderate intake protects brain health.

25 Sep 2025

Organophosphate pesticide exposure linked to reduced sperm quality in healthy men

This pilot study found that urinary metabolites of organophosphate pesticides were linked to reduced sperm motility in healthy young men, though results were preliminary. Oxidative stress did not explain the association, suggesting other biological pathways may be involved.

25 Sep 2025

Mount Sinai study maps protein networks driving Alzheimer’s disease pathogenesis

A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most comprehensive views yet of how brain cells interact in Alzheimer's disease, mapping protein networks that reveal communication failures and point to new therapeutic opportunities.

25 Sep 2025

Healthy habits linked to younger brain age

Your chronological age may say 65, but your brain could be acting a decade younger - or older - depending on your life experiences.

25 Sep 2025

Leading cancer organizations call for action to boost HPV vaccine coverage

VCU Massey Comprehensive Cancer Center, along with 61 other National Cancer Institute (NCI)-Designated Cancer Centers, several leading national cancer health organizations and the University of Puerto Rico Comprehensive Cancer Center, have endorsed a joint statement urging the nation's health care systems, health care providers, parents, caregivers and the public to choose the human papillomavirus (HPV) vaccination for cancer prevention.

25 Sep 2025

Groundbreaking MRI technique reveals microvascular pulsations in the aging brain

Researchers at the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have developed a groundbreaking brain imaging technique that reveals how tiny blood vessels in the brain pulse with each heartbeat-changes that may hold clues to aging and diseases such as Alzheimer's.

25 Sep 2025

UPR modulators show promise in treating cancer-related bone disease

Before a chain of amino acids can become an active and useful protein, it must be processed and folded into the appropriate conformation.

25 Sep 2025

Targeting TGF-β signaling as a strategy to treat liver fibrosis

Liver fibrosis, a pathological scarring process resulting from chronic liver injury, represents a significant global health burden due to its potential progression to cirrhosis and hepatocellular carcinoma.

25 Sep 2025

Colorectal cancer first presents with unexplained strokes and blood clots

A new case report was published in Volume 12 of Oncoscience on September 15, 2025, titled "When strokes reveal a hidden malignancy: An atypical case of metastatic colorectal cancer with extensive thromboembolism."

25 Sep 2025

Medical imaging radiation linked to small cancer risk in children

A recent study links exposure to radiation from medical imaging to a small-but-significant risk of blood cancers among children and adolescents.

25 Sep 2025

Genetic modification enhances "living drugs" for blood cancers

CAR T cells are patient-derived, genetically engineered immune cells. They are "living drugs" and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a "chimeric antigen receptor" (CAR) enables them to specifically recognize and attack cancer cells.

25 Sep 2025

New research explores pre-diagnostic indicators of dementia

A new study from Finland shows that low labor market participation for non-retirement related reasons may be an early indicator of dementia already years before the first evident symptoms occur. The study also identified other social markers that may be indicative of dementia up to ten years before a diagnosis of Alzheimer's disease, frontotemporal dementia or vascular dementia.

24 Sep 2025

Study shows dementia patients exposed to pollution had longer telomeres

Researchers studying a Swedish aging cohort found no overall link between air pollution and telomere shortening, a key marker of biological aging. Intriguingly, dementia patients exposed to higher pollution showed longer telomeres, though results were statistically non-significant.

24 Sep 2025