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Novel bladder cancer treatment gains MHRA approval in the UK

Johnson & Johnson has announced that the Medicines and Healthcare products Regulatory Agency (MHRA) has granted marketing authorization for BALVERSA®▼ (erdafitinib) as a monotherapy for the treatment of adults with unresectable or metastatic urothelial carcinoma (UC), the most common form of bladder cancer.

9 Nov 2024

HMGB1 as a key mediator in liver disease pathogenesis

Liver diseases, both acute and chronic, continue to pose significant clinical challenges due to high morbidity and mortality rates.

8 Nov 2024

New approach reinvigorates exhausted T cells to improve tumor control

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells - which have lost their cancer-fighting oomph - consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.

8 Nov 2024

Lupus Research Alliance launches first Translational Bridge Award to accelerate lupus treatments

The Lupus Research Alliance (LRA) is excited to announce the first-ever recipients of the Translational Bridge Award (TBA), established this year to accelerate the translation of groundbreaking research into potential treatments and diagnostics for lupus.

8 Nov 2024

Genetic diagnosis solves medical mystery for 30 undiagnosed patients

An international team of researchers has provided a genetic diagnosis for 30 individuals whose condition was undiagnosed for years despite extensive clinical or genetic testing.

8 Nov 2024

Uncovering the pathway behind ALS neurodegeneration

Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS) each year. On average, they survive for only two to five years after being diagnosed, according to the Centers for Disease Control and Prevention.

8 Nov 2024

Exploring the protective effects of HSD17B13 in hepatic steatosis

Chronic liver disease (CLD) is a growing global health challenge, accounting for millions of deaths each year. Its major contributors include metabolic dysfunction-associated steatohepatitis (MASH), alcoholic liver disease (ALD), and hepatitis C virus infection.

8 Nov 2024

Traditional and cutting-edge endoscopic modalities in colorectal cancer diagnosis

The evolution of gastrointestinal (GI) endoscopy has transformed CRC diagnostics since its early 20th-century origins.

8 Nov 2024

Exploring the current use and future of alternatives to traditional informed consent in acute stroke trials

The University of Cincinnati's Yasmin Aziz, MD, and Joseph Broderick, MD, coauthored an editorial published Nov. 7 in the journal Neurology analyzing the current use and potential future of alternatives to traditional informed consent in acute stroke trials.

8 Nov 2024

Exploring the anticancer potential of medicinal plants

Cancer remains one of the leading global causes of mortality, with an estimated increase in cases due to lifestyle, environmental, and genetic factors.

8 Nov 2024

New discovery could lead to better treatments for drug-resistant leukemia

Scientists from Duke-NUS Medical School and their collaborators have identified an inherited genetic variation prevalent among East Asians that contributes to drug resistance, driving the aggressive growth of cancer cells in patients with chronic myeloid leukemia.

8 Nov 2024

Study reveals inadequacy of time extensions for Braille users in complex exams

Students often appear for high-stakes tests that hold significant weight in determining their futures. One such examination, the Common Test for University Admissions, currently allows examinees using braille an extended examination time of 1.5 times the standard duration.

8 Nov 2024

Study reveals high prevalence of unrecognized cognitive impairment in vulnerable older adults

One of the first studies to investigate the prevalence of unrecognized cognitive impairment among patients seen at Federally Qualified Health Centers, has found that it is ubiquitous, especially among minoritized older adults.

8 Nov 2024

AI tool enhances diagnosis of long COVID in electronic health records

Investigators at Mass General Brigham have developed an AI-based tool to sift through electronic health records to help clinicians identify cases of long COVID, an often mysterious condition that can encompass a litany of enduring symptoms, including fatigue, chronic cough, and brain fog after infection from SARS-CoV-2.

8 Nov 2024

Exploring the intergenerational impact of adversity on mind-body health

The Brain & Behavior Research Foundation (BBRF) is hosting a free webinar, "Intergenerational Effects of Adversity on Mind-Body Health: Pathways Through the Gut-Brain Axis" on Tuesday, November 12, 2024, at 2:00 pm ET. The presenter, Bridget Laura Callaghan, Ph.D., is an Assistant Professor in the Department of Psychology at the University of California, Los Angeles (UCLA). At UCLA, Dr. Callaghan directs the Brain & Body Lab in the Department of Psychology and also heads the Mental Disorders and Pain research theme at the Goodman Luskin Microbiome Center.

8 Nov 2024