Gene News and Research

Latest Gene News and Research

The Black Death may have influenced the evolution of genes involved in immune responses against pathogens

Researchers gathered empirical evidence that past pandemics due to infectious pathogens shaped the present-day susceptibility of humans to diseases, such as autoimmune diseases.

24 Oct 2022

A novel approach for viral genomic surveillance

In a recent study posted to the bioRxiv* preprint server, researchers in the United States explored a novel technique to improve representation in viral genomic surveillance.

24 Oct 2022

Research suggests that ORF6 is a major SARS-CoV-2 innate immune antagonist

In a recent study posted to the bioRxiv* server, researchers in the United States demonstrated how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 6 (ORF6) protein contributes to viral pathogenesis and modulates the host's immune responses.

23 Oct 2022

Overview of the roles of neutrophils in systemic autoimmune and autoinflammatory diseases

Researchers assess the role of neutrophil extracellular traps (NETs) in systemic autoimmune and autoinflammatory disorders.

23 Oct 2022

Booster vaccinations in the elderly lead to impaired neutralization of SARS-CoV-2 and atypical B cells

Researchers examine neutralizing antibody responses against SARS-CoV-2 in elderly individuals who received one mRNA booster dose.

23 Oct 2022

Biochemical and structural evidence demonstrates Omicron mutations are better adapted to mouse ACE2 than to human ACE2

Researchers demonstrated the structural basis of how the receptor-binding domain nested Omicron mutations have adapted to mouse angiotensin-converting enzyme 2 rather than human ACE2.

22 Oct 2022

Study indicates that the major determinants of SARS-CoV-2 pathogenicity reside outside of the spike protein

Researchers at Boston University made a chimeric recombinant SARS-CoV-2 encoding the spike glycoprotein gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate.

22 Oct 2022

TANGO2 plays a role in heme homeostasis, research reveals

Heme, the iron-holding molecule that gives blood its red color, is essential for life. Yet, ironically, it can be quite toxic if not properly handled. In fact, numerous diseases – from various cancers to cardiovascular diseases – are associated with defects in heme homeostasis.

21 Oct 2022

Butterfly wing pattern ground plan is manipulated by non-coding regulatory DNA, study says

Butterfly wing patterns have a basic plan to them, which is manipulated by non-coding regulatory DNA to create the diversity of wings seen in different species, according to new research.

21 Oct 2022

Scientists discover molecular link between lung tumor growth and disrupted circadian rhythms

Scientists discovered an important molecular link between lung tumor growth and disrupted circadian rhythms, according to a new paper co-authored by a University of Rochester Wilmot Cancer Institute investigator and led by the Scripps Research Institute in California.

21 Oct 2022

Study reveals TBX20 as a vital regulator of direct human cardiac reprogramming

Mammalian hearts have almost no ability to grow new heart muscle cells, called cardiomyocytes, after birth. Thus, dead tissue after an adult heart attack is not repaired with new cardiomyocytes.

21 Oct 2022

Study reconsiders the recommended age for screening women with family history of breast cancer

A new study released in the American Cancer Society journal Cancer reconsiders guidelines for when to start screening with mammograms if a woman has a mother, sister, or daughter who was diagnosed with breast cancer.

21 Oct 2022

Building DNA-based synthetic condensates with programmable compositions and functionalities

Recent studies have shown that liquid-liquid phase separation – akin to how oil droplets form in water – leads to formation of diverse types of membraneless organelles, such as stress granules and nucleoli, in living cells.

21 Oct 2022

Surprising discovery in people of Polynesian ancestry offers clues to genetic underpinnings of high cholesterol

The discovery of a genetic variant that is relatively common among people of Polynesian ancestry, but incredibly rare in most other populations, is giving clues to the genetic underpinnings of high cholesterol in all people, according to new research led by University of Pittsburgh School of Public Health geneticists in partnership with several other groups, including the University of Otago and the Samoan health research community.

21 Oct 2022

New research could have major implications for minimally invasive, robotically delivered brain surgery

The early-stage research tested the delivery and safety of the new implantable catheter design in two sheep to determine its potential for use in diagnosing and treating diseases in the brain.

21 Oct 2022

Cedars Sinai experts remind men of their breast cancer risk

Although breast cancer is more common in women, during October, Breast Cancer Awareness Month, experts from Cedars-Sinai Cancer are reminding men that they are at risk as well. One in every 100 breast cancers in the U.S. is diagnosed in a man, according to the Centers for Disease Control and Prevention.

21 Oct 2022

MTCH2 acts as a doorway for proteins into the mitochondrial membrane, study reveals

Mitochondria - the organelles responsible for energy production in human cells - were once free-living organisms that found their way into early eukaryotic cells over a billion years ago.

20 Oct 2022

Scientists develop human salivary gland organoids to test SARS-CoV-2 infectivity

In a recent study published in the journal Nature Cell Biology, researchers demonstrated the susceptibility of salivary glands to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in vitro using an organoid culture model.

20 Oct 2022

Multiomics analysis identifies immunobiomarkers for COVID-19 severity in outpatients

In a recent study published in the journal eLife, researchers showed the utility of machine-learning models in identifying early immune signatures, which could reliably predict clinical and immunological outcomes in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected outpatients.

20 Oct 2022

Study uses pluripotent stem cell models to investigate stress response in PTSD patients

Stem cell-derived neurons from combat veterans with post-traumatic stress disorder (PTSD) react differently to a stress hormone than those from veterans without PTSD, a finding that could provide insights into how genetics can make someone more susceptible to developing PTSD following trauma exposure.

20 Oct 2022

Gene News and Research

Latest Gene News and Research

The Black Death may have influenced the evolution of genes involved in immune responses against pathogens

A novel approach for viral genomic surveillance

Research suggests that ORF6 is a major SARS-CoV-2 innate immune antagonist

Overview of the roles of neutrophils in systemic autoimmune and autoinflammatory diseases

Booster vaccinations in the elderly lead to impaired neutralization of SARS-CoV-2 and atypical B cells

Biochemical and structural evidence demonstrates Omicron mutations are better adapted to mouse ACE2 than to human ACE2

Study indicates that the major determinants of SARS-CoV-2 pathogenicity reside outside of the spike protein

TANGO2 plays a role in heme homeostasis, research reveals

Butterfly wing pattern ground plan is manipulated by non-coding regulatory DNA, study says

Scientists discover molecular link between lung tumor growth and disrupted circadian rhythms

Study reveals TBX20 as a vital regulator of direct human cardiac reprogramming

Study reconsiders the recommended age for screening women with family history of breast cancer

Building DNA-based synthetic condensates with programmable compositions and functionalities

Surprising discovery in people of Polynesian ancestry offers clues to genetic underpinnings of high cholesterol

New research could have major implications for minimally invasive, robotically delivered brain surgery

Cedars Sinai experts remind men of their breast cancer risk

MTCH2 acts as a doorway for proteins into the mitochondrial membrane, study reveals

Scientists develop human salivary gland organoids to test SARS-CoV-2 infectivity

Multiomics analysis identifies immunobiomarkers for COVID-19 severity in outpatients

Study uses pluripotent stem cell models to investigate stress response in PTSD patients

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